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History of the mRNA vaccine

Nearly every function in the human body is carried out by proteins. Cells are constantly manufacturing them using single-strand messenger RNA, which is made from a DNA template. Each strand of mRNA holds the information on how to make one type of protein. The cell reads the mRNA, follows the instructions and makes a protein.

mRNA is a recipe book for the body’s cells. The idea? Make precise edits to the recipe, inject people with it, sit back and watch the body make all the proteins you need.

 IMAGE: Anas Al Bounni-KUST Review

Viruses come in different shapes and sizes. Some are DNA viruses, which contain DNA that integrates with the host DNA in certain cells, using that cell’s replication mechanism to multiply. These viruses can activate cancer genes in the host — the human papillomavirus (HPV) is known to cause cervical cancer, for example.

RNA viruses carry RNA and do not integrate that RNA into a host’s DNA. Instead, the RNA is directed to the host ribosomes in cells, with the ribosomes replicating the virus. These viruses do not interact with host DNA.

Once inside the body, the cell reads the vaccine mRNA and begins to make harmless spike proteins of its own. From there, the body recognizes them as a foreign threat and launches an immune response, teaching itself to respond to spike proteins. Should the actual coronavirus come knocking, your cells now know what to do.

The main drawback to mRNA vaccines? The mRNA breaks down very easily. It needs to be delivered inside a protective fatty barrier and kept cold.

mRNA vaccines are a groundbreaking way to elicit an immune response and their real impact is just beginning. Their applications don’t stop at COVID-19; we might be able to figure out the recipe for a cancer or HIV vaccine.

mRNA VACCINE HISTORY

1961-mRNA discovered.

1963-Interferon induction by mRNA discovered.

1965-First liposomes produced.

1969-First proteins produced from isolated mRNA in lab.

1971-Liposomes first used for drug delivery.

1974-Liposomes first used for vaccine delivery.

1978-First liposome-wrapped mRNA delivery to cells.

1984-mRNA synthesized in lab.

1989-First time synthetic mRNA in liposomes is delivered to human cells.

1992-mRNA tested as a treatment in rats.

1993-First mRNA vaccines tested for influenza in mice.

1995-mRNA tested as cancer vaccine in mice.

2005-Discovery that modified RNA evades immune detection.

2013-First clinical trial of mRNA vaccine for infectious disease (rabies).

2020-First mRNA-based COVID-19 vaccine approved for emergency use.

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Humanoid robots reach new depths

Humanoid robots are used in industries from medicine, law enforcement and hospitality, to maintenance and disaster relief. But Stanford University has developed a deep-sea humanoid robot that is diving in the robotics pool at Khalifa University with an end goal of exploring marine robotics for sustainable ocean ecosystems.

The OceanOneK robot — designed and built by Oussama Khatib and his Stanford team — has been five years in the making and made its Abu Dhabi debut tasked with retrieving plastic waste from the Khalifa University marine robotics pool.

But the team has bigger plans for OceanOneK

Having completed testing in the pool at Stanford on the trifecta of robotic function integration — navigation, bimanual manipulation (reciprocal hand movements needing disparity between hand actions), vision and body-control — it was time to take OceanOneK out to sea.

The robot performed several dives around the Mediterranean, reaching close to 1,000 meters — a record depth — exploring sunken vessels and retrieving artifacts.

As team members operated the robot through its haptic interface (communication system), they were able to feel what the robot was touching.

“It was pretty amazing feeling something that no other human could touch. While it was a (haptically mediated experience), it was still an amazing connection,” says Adrian Piedra, a Ph.D. student in Khatib’s Stanford lab.

CAPTION: Stanford team shares in-field experience with OceanOneK IMAGE: Khalifa University

One of the vessels was Le Francesco Crispi, an Italian steamship torpedoed by the British while enroute from Italy to France in 1943. Delicate white coral has formed on the wreck, Khatib says, that the dive’s marine biologists were very excited to touch and then collect as samples. Also present and observed were iron-eating bacteria.

The robot was able to perform tasks for archaeology and for marine biology.

– Oussama Khatib

This is why a humanoid robot was essential for this project, adds Wesley Guo, another of the project’s Stanford Ph.D. students. “The way we control the robot is direct, as this helps the operator relate intuitively. The easiest way to do this is to have the body at a scale and shape similar to the human form. We also wanted it to appear non-threatening, as it will work in collaboration with human divers at different sites.”

A typical recreational diver can safely descend to about 30 meters – anything deeper requires specialized training and equipment. At 30 meters the pressure is approximately four times that at the surface. What happens to the human body beneath these depths depends on the person’s overall health and fitness levels. At 1,000 meters, the robot experiences 100 times the atmospheric pressure, team leader Khatib explains.

So, such robots are the key to deep-water exploration. And with more autonomy comes more skill sets.

Khatib says autonomy of a robot in the water is challenging, hence the haptic interface back to a human. But the goal is to diminish the need for human intervention as much as possible.

These deep-water diving robots, called remotely operated vehicles, or ROVs, are a new type of robot that can collect a lot of image data. “Operations under water require arms, hands and coordination between them, and that is what we’ve brought here with the OceanOne concept,” Khatib says.

“The interface we use goes beyond the visual – it delivers tactile-touch sensing using a haptic device. A haptic device allows humans to touch and feel what the robot is interacting with and permits one to guide the robot while it is executing delicate tasks. It acts as an avatar,” Khatib tells KUST Review.

“It interprets and affects movement and grasp request, maintains attitude and position for the human reference, and passes sensory information back to the human,” he says.

Human movement is just one of the considerations when building a robot like OceanOneK. The working environment must also be factored in. In this case that includes water and how it behaves.

Currents, for example, disrupt the intended movement, and this is where Khalifa University comes in.

The robotics pool at Khalifa University can simulate such environments, but under controllable conditions.

“Here, we can control the amount and direction of currents, we can control the waves, we can control those interactions in an ocean-like environment,” says Khatib.  “This is perfect for training and learning.”

CAPTION: Ku Robotics Pool IMAGE: Khalifa University

The Khalifa University robotics team will also work toward adding to the tasks the robot’s hands can carry out on their own.

“Full autonomy (without human intervention) will be the ultimate target; this, however, is challenging, and in the near-term humans will work with the robot to carry out tasks such as underwater valve-turning and plug-insertion,

Our objective is to increase the robot’s degree of autonomy while reducing the extent of human intervention.

– Lakmal Seneviratne, director of the Center for Autonomous Robot Systems and professor of mechanical engineering at Khalifa University

Stanford’s Khatib says these sensory-mechanical systems are also used out of the water in industries such as medicine, where a physician may interact through a haptic interface when not able to be present in the ICU. Similarly, the systems could be used for robots working on electrical grates or offshore platforms.

“In many of these applications we aim to distance humans from danger while connecting their skills to the task that must be carried out in that environment,” Khatib says.

CAPTION: Stanford and Khalifa University robotics collaboration IMAGE: Khalifa University

“There is a lot of work needed before taking these robots into the field, and Khalifa University offers a unique environment for this preparatory marine robotic study,” Khatib says. “We are also collaborating in other ways,” including curriculum development and teaching, as well as through research focus groups and workshops,” he adds.

“We look forward to more interaction with the researchers, faculty and students here.”

Among future joint projects: Khalifa University KUCARS and Stanford University Robotics Lab have recently established a collaboration to research and develop marine robotics systems for sustainable marine ecosystem applications, including ocean monitoring and ocean cleaning.

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Deciphering the potential of 3D
printed structures

According to data from the U.S. Census Bureau, the average house requires a span of seven months to materialize. This includes a cascade of developmental stages: the foundation is laid, the framing is erected, insulation is packed, drywall is hung, the plumbing installed, and the electrical grid established. This calls for a broad array of experts. Now, the construction industry is pivoting toward adopting 3D printing technologies to respond more nimbly, sustainably and affordably to the dynamic demands of modern homebuyers.

Japan, for example, has demonstrated the speed, building a house in 24 hours. While the resulting build serves as an office space now, its swift construction proves its potential for future home-building on a time crunch. Japan further showcased this by fabricating a spacious villa in 45 days.

Time may be money and this axiom resonates well in the world of 3D printed structures. Data from 3D print technology company, COBOD, suggests an economic advantage, with the cost of 3D homes approximately 45 percent lower than traditional construction methods. Personalization is also an option.

3D printers for home construction are essentially giant robots, capable of rendering virtually any design specifications a homeowner might dream up. Want a home shaped like a sphere? With 3D printing, such whimsical abodes could be actualized. Plus, these printed homes come with integrated reinforcement, which means no precast or additional reinforcements are required, making it a greener option.

In 2022, ICON, construction tech development company, and the Lennar Corporation, one of the leading home building companies in the U.S., announced a plan to 3D print an entire neighborhood of 100 homes. These solar-powered homes, ranging in size from 1,524 to 2112 square feet, offer a vision of a sustainable future community.

Projects like these pave the way for solving global issues, from the pervasive shortage of housing and scarcity of skilled labor, to the rehabilitation of regions hit by natural disasters. Swift and cost-effective structures could offer near-immediate shelter to communities affected by natural disasters or to the ubiquitous problem of homelessness. A 2022 report from Urbanet, highlights that over 1.8 million people globally lack adequate housing.

“There are far too many homeless people. Working-class people can’t afford basic housing in regular old American cities. Construction’s too wasteful. Houses aren’t energy-efficient enough. At the suburb scale, it’s dystopian, almost, what we’re getting, right? We’re supposed to be the most advanced version of humanity that’s ever existed and we can’t even meet this basic need properly,” Jason Ballard, CEO of ICON told The New Yorker.

The scope of 3D printing extends beyond the residential. As the 3D home-building market grows, other regions are exploring 3D printed structures for office buildings, bus stops and religious centers.

In 2020, the UAE was awarded the Guinness World Record for the first 3D-printed commercial building which served as the headquarters for the Dubai Future Foundation. After a swift 17-day print, followed by interior outfitting, it stands as a testament to rapid, efficient construction, offering up to 60 percent less waste.

The UAE is also home to the world’s largest 3D-printed building and plans to inaugurate the first 3D-printed, fully-functioning mosque by 2025.

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Vertical farms and 3D-printed reefs
part of UAE’s plans for food security

There are many reasons countries struggle with food insecurity: poverty, high populations in developing countries, conflict affecting supply chains, climate change and more. But some simply don’t have the temperate climate required to grow food and depend on outside sources.

The UAE is one such country, importing 90 percent of its food supply. And it isn’t waiting for global warming to affect the imports it has always relied on.

This doesn’t mean the country will do it alone. Part of the UAE’s National Food Strategy 2051 is to diversify international food sources through collaboration and trade, but the aim is to ensure food security. And that means getting creative.

The National in 2020 reported that the UAE government invested U.S.$100 million to bring in four agritech companies to explore how countries with hot and dry climates can use their technologies.

One of the companies is U.S. based Aero Farms. The company’s founder and chief executive, David Rosenberg, told The National, “Most places in the world, they don’t even want to be second. They want to be fifth or sixth, get it tried and true then come here, they say. In the UAE, you have boldness of ‘let’s do it bigger, better,’ and that was very attractive to us.”

Aero Farms in 2023 opened the world’s largest vertical-farming research-and-development center. The Abu Dhabi facility’s goal: Forge ahead with inside vertical farming and sustainable agriculture in dry regions.

But the UAE is not just looking at agricultural development, it’s also focused on the sea — in particular coral reefs.

According to URB, the Dubai-based company known for building sustainable cities and tasked with the reef project, coral reefs are one of the world’s most varied ecosystems.

The recently announced Dubai Reefs project plans to create an artificial, 3D-printed coral reef spanning 200 square kilometers.

The ultimate goals: Repair the coastline from oil dredging and building; generate more fish; and boost eco-tourism and research.

Caption: Underwater farming    Credit: URB

“Coral reefs provide an important ecosystem for life underwater whilst playing an important role in water filtration, fish reproduction, shoreline protection and erosion prevention,” the company says in promotional material for the project.

The bottom line when it comes to food security: More coral reefs equals more fish.

Coral reefs and their surrounding areas are home to 25 percent of all marine animals; 94 percent of the Earth’s wildlife live in the sea.

The project also aims to boost the tourism sector with eco lodges, eco resorts and a research center parked right in the middle of it all.

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Google Earth shines light
on ancient Roman camps

Aerial photographs, images produced from cameras attached to planes, rockets or satellites, are used for photogrammetry and interpretation — measurements (for topographical mapping) and the identification and purpose of objects. But it was a team of archaeologists scouring Google Earth that uncovered historical camps in the Arabian desert dating back to 106AD.

The images, experts believe, are of Roman camps built to house soldiers as they prepared for a takeover of the Nabataean Kingdom. The Arab nomads settled in the area now known as Jordan and built a wealthy trade empire.

But after thousands of years, and buried by sand, how are the camps identified and what makes them Roman?

The three camps, shaped like playing cards, are characteristic of how the Romans built their temporary camps 2,000 years ago. They would also dig a moat surrounding the camp, which contributes to how they are found.

The aerial imaging picks up differences in the density in the sand, carving out the identifying rectangular shape. Conclusions were drawn based on the location and the historical Roman takeover of the Nabataean civilization, famed for building the carved cliffs of Petra in what is now Jordan.

IMAGE: APAAME

Dr. Michael Fradley, research associate at Oxford University and part of the discovery team, says they initially identified the camps by reviewing satellite images taken from Google Maps. 

“If we had just found one camp it would be interesting, but we would only be able to make a limited interpretation of the site,” Fradley tells KUST Review. “In this case, with three camps laid out in a row, we are able to infer a great deal more about the sites because we are able to confidently say the direction in which the Roman army were traveling and their likely target. 

We can then conjecture that they link to the annexation of the Nabataean kingdom by the Emperor Trajan after 106 CE.”

These conclusions may also have changed thoughts about the nature of the Romans’ battle with the Nabataeans.

“Roman forts and fortresses show how Rome held a province, but temporary camps reveal how they acquired it in the first place,” says Dr. Mike Bishop, one of the researchers and an expert in the Roman military, in a statement released by Oxford University.

And all this because of a camera.

Aerial photography has been used as a tool for archaeologists in finding ancient ruins for over a century — the first being Stonehenge in the United Kingdom. And the development of technology over time has made it possible to find sites that have long since been buried.

Athol Yates, a humanities and social sciences professor at Khalifa University, says often, the key is using light detecting and ranging (LiDAR) technology. This is a laser-based technology that detects and measures distances to objects on the Earth’s surface and ultimately creates a distance map of the object in the area.

­­­­­­­­­­­­­­“Because the settlements are often dug up, and the Romans did this all the time, they dug a moat and built a wall.

This (moat) eventually gets filled in over time but it’s less dense than the normal soil is, so when you’re using LiDAR, there will always be a depression, making it easy to spot,” Yates tells KUST Review.

Essentially, the laser fires toward the object, bouncing off its target and back to the emitting source. The time it takes to travel back allows for the measurement of distance.

“It reveals actual inundations. It’s not ground-penetrating radar, it’s just reflecting off solid things,” he says.

Khalifa University’s Athol Yates

The laser is able to bypass even the most overgrown landscapes as it can pass through leaves and the smallest spaces between tree branches, which contributes to its accuracy. As the cost reduces, LiDAR is being used across many industries.

The technology is also used in urban planning, geographical surveying, video games, movies and autonomous vehicles. It is also used by police to monitor cars zipping past on the highway — this means you can thank it for your speeding tickets.

Fradley, of the discovery team says they don’t use LiDAR in their work, “It was just through luck that our colleagues in Aerial Photographic Archive for Archaeology in the Middle East would be flying in Jordan not long after we identified the sites, and were able to take these more detailed aerial photographs of the western and central camps.”

The paper of the discovery of the Roman camps was published in Antiquity in 2023.