Mini 3D-printed lungs enhance
disease research

Using light-based printing, a miniature 3D-printed human lung model was created by Canadian researchers at the University of British Columbia.

The team’s tiny lung creation mimics real human airways including airway-lining cells, connective tissue cells and mini blood vessels.

The structure is printed with a special gel-like material that supports healthy cell growth and behavior. When exposed to cigarette smoke extract, it responded just like real lung tissue — releasing inflammation signals such as IL-6 and IL-8, without harming the cells.

The model also contains features like fibroblasts that move to heal soft tissue and endothelial cells forming vessel-like layers.

It’s a more realistic, customizable platform for studying lung diseases and testing treatments and offers a new tool that could help replace animal testing and improve research on asthma, COPD and more.

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From plastic mess to manageable

Plastic waste is piling up, and while recycling bins are everywhere, only a small chunk of that plastic gets reused. But engineers might be onto something big. A new review in Industrial & Engineering Chemistry Research says that a field called process systems engineering (PSE) could be the secret weapon needed to turn our plastic mess into something more manageable.

PSE uses smart tech like optimization software, computer modeling and machine learning to determine the best ways to sort, recycle and transport plastic waste — making the job smarter, faster and cleaner.

The review shares some up-and-coming methods, like solvent-based recycling and chemical recycling that could tackle the hard-to-recycle items that are typically thrown in the trash.

These methods might even beat traditional recycling when it comes to cutting emissions and saving more of the original material.

These new systems, however, still face major roadblocks: high costs, limited infrastructure, and questions about how to scale them up without causing new problems.

Even bioplastics, which are made from plants and seem like a greener choice, have downsides — like needing a lot of land and water to produce.

There’s no silver bullet yet, but using systems engineering to look at the whole picture — from environmental impact to social fairness — could help us build smarter plastic solutions.

It’s all part of an idyllic circular economy where plastics don’t end up in landfills, oceans or your lunch.

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A surgical cut for ulcerative colitis

Twenty to 30 percent of people with ulcerative colitis will typically require surgery to remove sections of the colon and the rectum (colectomy). This can leave an individual with an altered quality of life, but treatment advances are offering options whereby surgery isn’t necessarily the go-to option

A 20-year study out of Lothian, Scotland, has shown a more than 90 percent drop in the number of people requiring this surgery.

Biologics and small-molecule drugs have reduced the need for surgery over the past two decades. By 2023 these surgeries had become uncommon and advanced therapy use grew.

These treatments, including newer options like vedolizumab and medications that block the activity of Janus kinases, are now often the first thing doctors try — especially for older patients.

And it’s not just about fewer surgeries. The study found that emergency operations also became less common, and there were no signs that newer meds made surgery riskier for those who still needed it.

While researchers can’t say for sure that the drugs were the reason for the drop in surgery, the timing lines up well.

Ultimately, ulcerative colitis care is improving, becoming smarter and significantly less invasive — thanks to modern medicine.

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Mapping hidden kidney damage

PathoPlex is a new high-tech imaging tool that works like a disease detective finding hidden problems in tissue samples, typically missed by standard microscopes.

The tool, featured in Nature, can track more than 140 proteins at ultra-high resolution. It works in conjunction with a software called Spatiomic that helps to make sense of the data, noting patterns revealing stress, damage and treatment effects at the cellular level.

When scientists tested PathoPlex on kidney diseases, it picked up early signs of trouble.

In immune-related conditions, it identified a protein called JUN that marks disease progression.

In diabetes, it succeeded in locating stress and cell damage even when tissue appeared normal under a regular microscope.

It also showed how diabetes drugs like SGLT2 inhibitors can ease some of this hidden stress.

PathoPlex could help doctors catch kidney disease earlier and treat it more effectively — turning hidden clues into a clear path of action.

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Quantum sensors push precision measurements to new heights

From brain scans to spacecraft navigation, measuring physical quantities like time, energy, or electric and magnetic fields with extreme precision is central to modern science and technology. In hospitals, for instance, magnetic field detection powers MRI machines. In mining or space exploration, accurate sensing of accelerations helps us navigate and understand unfamiliar environments.

Victor Montenegro

Khalifa University’s Victor Montenegro holds a doctorate in physics. Outside of his academic work, he is an amateur guitar player who enjoys photography and reading widely across genres.

Now, a new wave of ultra-sensitive tools – quantum sensors – is pushing these capabilities even further. Thanks to the bizarre but powerful properties of quantum physics, these sensors can detect tiny changes in their environment with unprecedented accuracy. As a result, they’ve become a hot topic in scientific research.

The simplest starting point for quantum sensors is measuring just one unknown quantity — like a magnetic field or time — while assuming everything else is already known and under control. This clean setup is not only elegant but also lets quantum devices push precision to its ultimate limit. But the real world is far from this ideal scenario. In many practical situations, several things are unknown at once. This more complex challenge, called multiparameter quantum sensing, makes everything trickier – from designing the quantum sensor itself to figuring out how well it can perform.

To tackle the challenges of sensing multiple unknowns at once, scientists use a powerful mathematical tool called the Fisher information matrix. Think of it as a way to measure how much useful information a quantum sensor picks up. Loosely speaking, the larger the Fisher information, the higher the accuracy for estimating the parameter in question. But there’s a catch: sometimes, this matrix can become singular, meaning it can’t be used to estimate the parameters at all. It makes the sensing impossible. This breakdown can happen for a few reasons, for instance, maybe the measurements just aren’t chosen appropriately, or maybe the parameters we thought were independent are actually tangled together in the quantum system.

This new approach lets you ask, in principle, different questions in sequence, learning more from how the system responds over time.

My team at the College of Computing and Mathematical Sciences at Khalifa University, along with collaborators from the University of Electronic Science and Technology in China, has tackled this long-standing problem in quantum sensing: what to do when the information matrix breaks down. Our solution? A surprisingly simple but powerful idea – measure the system multiple times in a row – rather than just once.

This method, known as a sequential measurement strategy, only requires keeping track of how the outcomes change step by step. It works even if you’re looking only at a small part of the system. Unlike conventional sensing – which is like asking the same question again and again – this new approach lets you ask, in principle, different questions in sequence, learning more from how the system responds over time.

Because each measurement builds on the last, hidden connections between outcomes start to emerge. These correlations help untangle the unknowns and fix the problem of singular information matrices – all without adding much extra complexity. It’s a novel and unconventional strategy that opens the door to smarter, more efficient quantum sensing.

To show just how practical this strategy is, the team tested it on two very different quantum systems. The results were clear: This sequential sensing approach works across a wide range of setups, keeps the experimental demands low, and still delivers highly accurate estimates.

Read the paper here.