A new study published in Nature Medicine identifies a new type of brain lesion in patients with multiple sclerosis (MS) that might be an indicator of fast disease progression.

These broad rim lesions (BRLs) were mainly discovered in those whose MS progressed quickly, indicating they are an important clue for doctors.

BRLs are like hotspots of inflammation. They have a thick, active outer layer that is filled with immune cells that appear to create discord in the spinal cord and brain. Patients with these lesions were more prone to quicker disability and had more damage in essential parts of the nervous system.

By studying donor brain tissue and using high-tech imaging like PET scans, researchers were able to identify the lesions while people were still living. They were also able to identify a unique pattern of gene activity in BRLs and signs of stress inside cells.

Notably, the lesions may be used to predict the potential rapid decline of MS patients. Additionally, the research team identified possible targets for new treatments that may help to slow or stop the damage.

The findings may assist in earlier diagnosis, more effective treatment and possible new drugs for those facing aggressive forms of MS.

More like this: Launching medical research